Bioelectrochemistry in protein ion channels and charged interfaces
Structure-function relationships in membrane proteins (bacterial porins, mitochondrial porins). Theoretical modelling of ion transport based on 3D atomic structure. MD simulations. Continuum models (Poisson-Boltzmann, Poisson-Nernst-Planck). Electrostatic calculations: pKa determination. Statistical Mechanics. Thermodynamics. Electrophysiology. Ion channel reconstitution into planar membranes. Noise analysis. Nanopores and other biomimetic materials.
Biophysical characterization of membrane permeabilization induced by biologically active compounds
Viral proteins (SARS-CoV E, MERS , SH, CSFV p7, etc). Pulmonary surfactant (SP-B, SP-C hydrophobic proteins). Amphiphilic macroanions (COSAN). Electrophysiology. Ion channel reconstitution into planar membranes. Noise analysis. Continuum models (Poisson-Nernst-Planck). Electrostatic calculations: pKa determination.
Electrical and mechanical characterization of synthetic membranes and biomaterials
Gas permeability. Impedance spectroscopy. Differential Scanning Calorimetry. New materials for batteries, fuel cells. Biomedical applications. Contact Lenses: Theoretical and numerical modeling.